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LDH-A  顺利获得上调 ZEB2 促进肠型胃癌上皮间质转化

 

Authors Zhang Y, Lin S, Chen Y, Yang F, Liu S

Received 24 January 2018

Accepted for publication 11 March 2018

Published 27 April 2018 Volume 2018:11 Pages 2363—2373

DOI http://doi.org/10.2147/OTT.S163570

Checked for plagiarism Yes

Review by Single-blind

Peer reviewers approved by Dr Andrew Yee

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Geoffrey Pietersz

简介：浸润和转移是胃癌复发和死亡的重要原因。顺利获得体外研究发现乳酸脱氢酶 A (LDH-A) 顺利获得上调 ZEB2 促进肠型胃癌细胞浸润和转移。LDH-A  和 ZEB2 密切相关性在 371 例肠型胃癌组织标本中的到证实。生存分析结果显示： LDH-A 和 ZEB2 联合表达患者预后更差。因此，LDH-A  和 ZEB2 的相关性可能为肠型胃癌给予治疗策略。
Keywords: intestinal-type gastric cancer, LDH-A, ZEB2, epithelial–mesenchymal transition, Warburg effect, glycolysis


 

摘要视频链接：Lactate dehydrogenase A




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