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    已发表论文

    自噬功能障碍顺利获得增强 γ 分泌酶复合物的活性使 β-淀粉样蛋白肽显著增高

     

    Authors Cai Z, Zhou Y, Liu Z, Ke Z, Zhao B
    Received 17 March 2015
    Accepted for publication 21 April 2015
    Published 17 August 2015 Volume 2015:11 Pages 2091—2099
    DOI http://dx.doi.org/10.2147/NDT.S84755
    Checked for plagiarism Yes
    Review by Single-blind
    Peer reviewer comments 6
    Editor who approved publication:  Professor Wai Kwong Tang

    Abstract: Numerous studies have shown that autophagy failure plays a critical role in the pathogenesis of Alzheimer’s disease, including increased expression of beta-amyloid (Aβ) protein and the dysfunction of Aβ clearance. To further evaluate the role of autophagy in Alzheimer’s disease, the present study was implemented to investigate the effects of autophagy on α-secretase, β-secretase, or γ-secretase, and observe the effects of autophagy on autophagic clearance markers. These results showed that both autophagy inhibitor and inducer enhanced the activity of α-, β-, and γ-secretases, and Aβ production. Autophagy inhibitor may more activate γ-secretase and promote Aβ production and accumulation than its inducer. Both autophagy inhibitor and inducer had no influence on Aβ clearance. Hence, autophagy inhibitor may activate γ-secretase and promote Aβ production and accumulation, but has no influence on Aβ clearance.
    Keywords: Alzheimer’s disease, autophagy, beta-amyloid, secretases


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