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已发表论文

肌萎缩侧索硬化症的神经功能恢复的进度

 

Authors Chen L, Huang H, Xi H, Mao G
Received 26 September 2014
Accepted for publication 23 December 2014
Published 6 August 2015 Volume 2015:3 Pages 109—114
DOI http://dx.doi.org/10.2147/JN.S74145
Checked for plagiarism Yes
Review by Single-blind
Peer reviewer comments 5
Editor who approved publication:  Prof. Dr. Hari Shanker Sharma


Abstract: Amyotrophic lateral sclerosis is a progressive and fatal neurodegenerative disease characterized by progressive paralysis and motor neuron death. In addition to symptomatic managements such as ventilation and nutritional support, neurorestorative therapies have demonstrated anti-neurodegenerative potential and may improve quality of life for patients. Currently, clinical neurorestorative strategies include pharmacological management (granulocyte colony stimulating factor), neuromodulatory intervention (repetitive transcranial magnetic and cortical stimulation), cell transplantation (bone marrow stromal cells, olfactory ensheathing cells, granulocyte colony stimulating factor-mobilized peripheral blood stromal cells, hematopoietic stem and progenitor cells, neural stem/progenitor cells, CD133+ cells and CD34+ cells), bioengineering and tissue engineering therapy, and combined neurorehabilitative treatment. In this review, we describe the latest progress in clinical neurorestorative management of amyotrophic lateral sclerosis and discuss the underlying evidence base.
Keywords: amyotrophic lateral sclerosis, neurorestorative treatment, cell transplantation, clinical trial


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