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已发表论文

Brentuximab vedotin 用于治疗复发性或难治性霍奇金淋巴瘤

 

Authors Chen R, Chen B

Published Date March 2015 Volume 2015:9 Pages 1729—1733

DOI http://dx.doi.org/10.2147/DDDT.S82007

Received 1 February 2015, Accepted 20 February 2015, Published 23 March 2015

Abstract: Brentuximab vedotin is a promising antibody–drug conjugate (ADC) targeting CD30 of tumor cells. It selectively delivers monomethyl auristatin E (MMAE) into CD30-expressing cells and induces tumor cell apoptosis. Various clinical trials have provided evidence that it is effective in relapsed or refractory Hodgkin’s lymphoma (HL), and it has also shown its advantages in other CD30-positive lymphomas. In this review, we focus on the structure, mechanisms, and pharmacokinetics of brentuximab vedotin. We also summarize clinical trials with brentuximab vedotin and make recommendations for brentuximab vedotin in the treatment of relapsed or refractory HL.
Keywords: lymphoma, CD30-positive, clinical trials, tumor cells, antitumor effects, monoclonal antibody


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