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已发表论文

同种异体造血干细胞移植后急性淋巴细胞白血病复发的预防和治疗

 

Authors Chen R, Campbell JL, Chen B

Published Date February 2015 Volume 2015:8 Pages 405—412

DOI http://dx.doi.org/10.2147/OTT.S78567

Received 2 December 2014, Accepted 22 December 2014, Published 10 February 2015

Approved for publication by Professor Daniele Santini


Abstract: Relapse of acute lymphoblastic leukemia remains a major cause of death in patients following allogeneic hematopoietic stem cell transplantation. Several factors may affect the concurrence and outcome of relapse, which include graft-versus-host disease, minimal residual disease or intrinsic factors of the disease, and transplantation characteristics. The mainstay of relapse prevention and treatment is donor leukocyte infusions, targeted therapies, second transplantation, and other novel therapies. In this review, we mainly focus on addressing the impact of graft-versus-host disease on relapse and the prophylaxis and treatment of acute lymphoblastic leukemia relapse following allogeneic hematopoietic stem cell transplantation. We also make recommendations for critical strategies to prevent relapse after transplantation and challenges that must be addressed to ensure success.

Keywords: acute lymphoblastic leukemia, relapse, allogeneic hematopoietic stem cell transplantation, prevention, therapy


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