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已发表论文
自组装的表面活性剂类多肽 A6K 作为疏水性药物的潜在传送系统
Authors Chen Y, Tang C, Zhang J, Gong M, Su B, Qiu F
Published Date January 2015 Volume 2015:10 Pages 847—858
DOI http://dx.doi.org/10.2147/IJN.S71696
Received 24 July 2014, Accepted 1 December 2014, Published 23 January 2015
Background: Finding a suitable delivery system to improve the water solubility of
hydrophobic drugs is a critical challenge in the development of effective
formulations. In this study, we used A6K, a self-assembling
surfactant-like peptide, as a carrier to encapsulate and deliver hydrophobic
pyrene.
Methods: Pyrene was mixed with A6K by magnetic stirring to form a suspension. Confocal laser scanning microscopy, transmission electron microscopy, dynamic light scattering, atomic force microscopy, fluorescence, and cell uptake measurements were carried out to study the features and stability of the nanostructures, the state and content of pyrene, as well as the pyrene release profile.
Results: The suspension formed contained pyrene monomers trapped in the hydrophobic cores of the micellar nanofibers formed by A6K, as well as nanosized pyrene crystals wrapped up and stabilized by the nanofibers. The two different encapsulation methods greatly increased the concentration of pyrene in the suspension, and formation of pyrene crystals wrapped up by A6K nanofibers might be the major contributor to this effect. Furthermore, the suspension system could readily release and transfer pyrene into living cells.
Conclusion: A6K could be further exploited as a promising delivery system for hydrophobic drugs.
Keywords: pyrene, self-assembling peptide, micelles, nanofibers, drug delivery
Methods: Pyrene was mixed with A6K by magnetic stirring to form a suspension. Confocal laser scanning microscopy, transmission electron microscopy, dynamic light scattering, atomic force microscopy, fluorescence, and cell uptake measurements were carried out to study the features and stability of the nanostructures, the state and content of pyrene, as well as the pyrene release profile.
Results: The suspension formed contained pyrene monomers trapped in the hydrophobic cores of the micellar nanofibers formed by A6K, as well as nanosized pyrene crystals wrapped up and stabilized by the nanofibers. The two different encapsulation methods greatly increased the concentration of pyrene in the suspension, and formation of pyrene crystals wrapped up by A6K nanofibers might be the major contributor to this effect. Furthermore, the suspension system could readily release and transfer pyrene into living cells.
Conclusion: A6K could be further exploited as a promising delivery system for hydrophobic drugs.
Keywords: pyrene, self-assembling peptide, micelles, nanofibers, drug delivery
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