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残余胆固醇与体重指数联合对高血压的影响：一项针对中国成年人的全国队列研究
Authors Xiong YJ , Shao DM, Zhu XY, Lv T
Received 8 January 2025
Accepted for publication 25 March 2025
Published 30 March 2025 Volume 2025:18 Pages 1813—1825
DOI http://doi.org/10.2147/JMDH.S516335
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Charles Victor Pollack
Yu-Jun Xiong,1 Da-Ming Shao,2 Xing-Yun Zhu,3 Tian Lv4
1Department of Gastroenterology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China; 2Department of Rheumatology, The University of Chicago Medical Center, Chicago, IL, The United States of America; 3Department of Endocrinology, Beijing Jishuitan Hospital, Beijing, People’s Republic of China; 4Department of Neurology, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang Province, People’s Republic of China
Correspondence: Tian Lv, Department of Neurology, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang Province, People’s Republic of China, Email lt627756@163.com
Background: Hypertension, a major global health concern, is closely associated with obesity and lipid abnormalities. Remnant cholesterol (RC), a triglyceride-rich lipoprotein component, has been linked to cardiovascular diseases, but its joint impact with body mass index (BMI) on hypertension risk remains unclear.
Methods: We analyzed data from 3805 participants (mean age: 57 years; 44.3% male) in the China Health and Retirement Longitudinal Study (CHARLS) from 2011– 2020. Inclusion criteria were adults aged over 45 years with complete data on blood lipids and BMI. Participants with baseline hypertension or missing covariate data were excluded. Cox proportional hazard models assessed associations, while mediation analysis explored RC’s role in BMI-hypertension linkage.
Results: Over a 9-year follow-up, 590 participants developed hypertension. Obesity (BMI ≥ 28.0 kg/m²) and high RC levels were independently associated with hypertension (HR: 2.18; 95% CI: 1.48– 3.21 for the highest RC tertile). RC mediated 7.07% of BMI’s effect on hypertension, and BMI mediated 29.3% of RC’s effect.
Conclusion: This study highlights the intertwined roles of BMI and RC in hypertension development. Targeting both risk factors may enhance prevention strategies.
Keywords: CHARLS, hypertension, BMI, remnant cholesterol, mediating effect
