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已发表论文

CP-673451，血小板衍生的生长因子受体抑制剂，抑制肺癌细胞的增殖和迁移

 

Authors Xi YL, Chen M, Liu XM, Lu ZM, Ding Y, Li DT

Published Date July 2014 Volume 2014:7 Pages 1215—1221

DOI http://dx.doi.org/10.2147/OTT.S62946

Received 24 February 2014, Accepted 8 April 2014, Published 3 July 2014

Abstract: Lung cancer is the leading cause of cancer mortality in the world. Although some advances in lung cancer therapy have been made, patient survival is still poor. The platelet-derived growth factor receptors (PDGFRs) and their ligands play critical roles in the regulation of many cancer cell processes, including cell survival and cell motility. Herein, we investigate the anticancer activities of CP-673451, a potent selective inhibitor of PDGFR kinase, in non-small-cell lung cancer (NSCLC) therapy. We found that CP-673451 is effective at suppressing cell viability, inducing cell apoptosis, and inhibiting cell migration and invasion by suppressing the PDGFR downstream signaling pathway in NSCLC cells. Furthermore, CP-673451 is effective at suppressing NSCLC tumor growth in vivo. In summary, our studies suggest that CP-673451 might be a promising therapeutic compound for NSCLC.

Keywords: CP-673451, platelet-derived growth factor receptors (PDGFRs), lung cancer, proliferation, migration


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