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已发表论文

索拉非尼 (Sorafenib) 在中国肾细胞癌患者治疗中的关键评价

 

Authors Ye DW, Zhang HL

Published Date June 2014 Volume 2014:7 Pages 925—935

DOI http://dx.doi.org/10.2147/OTT.S41828

Received 9 August 2013, Accepted 4 November 2013, Published 6 June 2014

Abstract: Renal cell carcinoma (RCC) accounts for 3% of all malignancies, and is the most aggressive cancer of the genitourinary system. Metastatic RCC is naturally resistant to chemotherapy and radiotherapy, and immunotherapy is of little benefit. In recent years, the emergence of molecular-targeted therapies has largely changed the therapeutic approach to metastatic RCC. These novel multikinase inhibitors have now become first-choice therapy because of their activity in inhibiting both cell proliferation and tumor angiogenesis. Sorafenib is the first tyrosine kinase inhibitor found to be effective in treating patients with metastatic RCC. Due to its good efficacy and safety, this agent is recommended as both first-line and second-line therapy for metastatic RCC in the People's Republic of China. Sorafenib seems to be more effective in patients of Chinese ethnicity than in western patients, and is well tolerated with a manageable toxicity profile, even at higher dosages and when used in combination with other anticancer agents. Novel biomarkers for predicting the efficacy of sorafenib have potential clinical value for guiding individualized targeted therapy.

Keywords: kidney cancer, renal cell carcinoma, sorafenib, tyrosine kinase inhibitor


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