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已发表论文

别嘌醇导致的瞬时低纤维蛋白原血症

 

Authors Yin ZQ, Xu JL, Li YQ, Xia JP, Luo D

Published Date September 2014 Volume 2014:8 Pages 1231—1233

DOI http://dx.doi.org/10.2147/DDDT.S66868

Received 27 April 2014, Accepted 30 May 2014, Published 2 September 2014

Abstract: This study reports a case of an 80-year-old male who suffered from drug eruption due to oral allopurinol for the treatment of gout. This patient complained of widespread erythema and maculopapule with itch, and small quantities of purplish-red rash with diffused distribution on four limbs were noted. After he was hospitalized, the area with purpuric rash increased in size, and hypofibrinogenemia was found. After treatment with intravenous infusion of fibrinogen and cryoprecipitate, and continued treatment with high-dose methylprednisolone, the skin rash gradually went away. This is the first report of purpura and hypofibrinogenemia induced by allopurinol and the pathophysiology underlying this reaction remained unknown.
Keywords: purpura, fibrinogen, drug eruption, gout






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